
Idiopathic tremor (ET), also known as essential tremor, is a neurological disorder characterized by involuntary and rhythmic tremors, mainly of the hands, but also of the head, voice, or other parts of the body. Although it is not a life-threatening condition, it can significantly affect the quality of life of patients. Causes and Pathogenesis The exact cause of essential tremor is not fully understood. However, it is believed to be related to dysfunction of certain areas of the brain, such as the cerebellum and thalamus, which are involved in movement control. There is evidence that ET may have a genetic basis, as in many cases a family predisposition is observed. About 50% of patients have first-degree relatives with the same disorder, which suggests an autosomal dominant mode of inheritance.
Symptoms
The main symptoms of essential tremor include:
Hand tremor: This is mainly observed when the patient performs an action, such as holding a glass or writing.
Head tremor: This may manifest as "yes-no" or "up-down" movements.
Voice tremor: Causes fluctuations in the tone of the voice.
Leg tremor (less common): Usually does not affect walking.
Worsening with stress, fatigue, or consumption of caffeine.
Differential Diagnosis
Essential tremor must be differentiated from other neurological conditions, such as:
Parkinson's disease: Parkinson's tremor usually occurs at rest and is accompanied by other symptoms, such as bradykinesia and rigidity.
Dystonia: Can cause irregular tremors with changes in posture.
Drug-induced tremor: Caused by the use of certain drugs (e.g., beta-agonists, antipsychotics).
Metabolic disorders: Such as hyperthyroidism or hypoglycemia.

Diagnosis
The diagnosis of essential tremor is based primarily on the medical history and on the neurological examination. There are no specific laboratory tests, but the doctor may order imaging tests (e.g., MRI) or blood tests to rule out other conditions.
Management and Treatment
Treatment of essential tremor depends on the severity of the symptoms and their impact on the patient's daily life.
Medication
B-blockers (e.g., propranolol): They are among the most effective treatments, especially for hand tremor.
Antiepileptics (e.g., primidone, topiramate): They help in cases where propranolol is not effective
Sedatives (e.g., benzodiazepines): They are mainly used in cases of tremor that is worsened by anxiety.
Botox: Used for head and voice tremors.
Interventional Therapies
Deep Brain Stimulation (DBS): Surgical placement of electrodes in the brain's thalamus to reduce tremor.
MRI-guided Focused Ultrasound (MRgFUS): Newer technique that uses focused ultrasound to destroy the area of the brain that is causing the tremor.
Lifestyle Changes
Reducing caffeine and alcohol.
Managing stress with relaxation techniques.
Physical therapy and occupational therapy to improve movement control.
Conclusion
Essential tremor is a common neurological disorder that can affect daily life, but there are many treatments available for its management. Early diagnosis and appropriate treatment can help patients maintain a functional and satisfying life.
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